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Moreover, the route of administration (e.g., intraperitoneal, intravenous, oral, or local injection) can substantially alter agent bioavailability, distribution, and pharmacodynamics, which in turn impacts tissue targeting and effectiveness

doi: 10.1016/j.virusres.2023.199203 445 BaikerikarS

A protocol can be considered operational, if the EEG is modulated in accordance with instructions, even though such changes might not always be accompanied by cognitive or behavioral changes